Cart
sales@molnova.com
Darunavir ethanolate
CAS No. 635728-49-3
Darunavir ethanolate ( TMC-114;UIC-94017 )
Catalog No. M15408 CAS No. 635728-49-3
A potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 50 | In Stock |
|
| 25MG | 87 | In Stock |
|
| 50MG | 147 | In Stock |
|
| 100MG | 237 | In Stock |
|
| 200MG | 354 | In Stock |
|
| 500MG | 581 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDarunavir ethanolate
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM.
-
DescriptionA potent, selective HIV-1 protease inhibitor that is extremely potent against laboratory HIV-1 strains and primary clinical isolates with IC50 of 3 nM, IC90 of 9 nM; blockes the infectivity and replication of HIV-1(NL4-3) variants with IC50 of 3-29 nM, also potent against multi-PI-resistant clinical HIV-1 variants isolated from patients; used to treat and prevent HIV/AIDS.HIV Infection Approved
-
SynonymsTMC-114;UIC-94017
-
PathwayMicrobiology/Virology
-
TargetHIV
-
RecptorWTHIV-1protease
-
Research AreaInfection
-
IndicationHIV Infection
Chemical Information
-
CAS Number635728-49-3
-
Formula Weight593.73
-
Molecular FormulaC29H43N3O8S
-
Purity>98% (HPLC)
-
Solubility10 mM in DMSO
-
SMILESCCO.CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CO[C@@H]3[C@H]2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N
-
Chemical NameCarbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester, compd. with ethanol (1:1)
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
2. Koh Y, et al. Antimicrob Agents Chemother. 2003 Oct;47(10):3123-9.
3. King NM, et al. J Virol. 2004 Nov;78(21):12012-21.
-
Atazanavir
A highly potent HIV-1 protease inhibitor that exhibits potent anti-HIV activity EC50 of 2.6-5.3 nM and EC90 of 9-15 nM in cell culture.
-
MPG, HIV related
MPG, HIV related is 27-aa peptide, derived from both the nuclear localisation sequence of SV40 large T antigen and the fusion peptide domain of HIV-1 gp41 and is a potent delivery agent for the generalised delivery of nucleic acids and of oligonucleotides into cultured cells.
-
Apelin-36 (rat, mous...
Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro (EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ.
